tPA (Alteplase) Dosage

Calculate tPA dose for acute ischemic stroke.

Emergent Calculation

Weight

Time is Brain: Every minute delay in treatment results in the loss of 1.9 million neurons.

Dosing Protocol

Total Score63.0mgCap: 90mg

Bolus (1m)6.3mg

Infuse (1h)56.7mg

Give 6.3mg IV bolus over 1 min, then56.7mg infusion over 60 mins.

NINDS/AHA Stroke Protocol

Disclaimer: This tool is for informational purposes only and is not a substitute for professional medical advice.

About this calculator

Overview

tPA: 0.9 mg/kg. Within 4.5 hours.

Fun Facts

Formula: Dose = 0.9 mg/kg. 10% bolus, 90% infusion.